Inhibitors of N (alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F10%3A00342427" target="_blank" >RIV/61388963:_____/10:00342427 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Inhibitors of N (alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency

Original language description

A series of N?-acyl(alkyl) and N (alpha)-alkoxycarbonyl-derivatives of L- and D-ornithine were prepared, characterized and analyzed for their potency toward the bacterial enzyme N (alpha)-acetyl-L-ornithine deacetylase. N (alpha)-chloroacetyl-L-ornithinewas the best inhibitor tested providing an IC50 value of 85 (mu)M.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

<a href="/en/project/IAA400550614" target="_blank" >IAA400550614: Synthesis and characterization of new potent inhibitors of enzymes dapE and argE with selective antimicrobial effect on resistant pathogenic bacterial strains</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Amino Acids

ISSN

0939-4451

e-ISSN

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Volume of the periodical

38

Issue of the periodical within the volume

4

Country of publishing house

AT - AUSTRIA

Number of pages

10

Pages from-to

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UT code for WoS article

000276423300020

EID of the result in the Scopus database

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