Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F11%3A00364530" target="_blank" >RIV/61388963:_____/11:00364530 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/cbic.201100066" target="_blank" >http://dx.doi.org/10.1002/cbic.201100066</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cbic.201100066" target="_blank" >10.1002/cbic.201100066</a>

Result language
angličtina
Original language name
Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study
Original language description
Lucifensin, a novel insect defensin of medicinal maggots identified recently in our laboratory, is 40 amino acid residues and three intramolecular bridges peptide. Oxidative folding of linear lucifensin precursor prepared by solid phase peptide synthesisresulted in a peptide with a pattern of disulfide bridges identical to that of native lucifensin. Synthetic lucifensin was active against Gram-positive bacteria and was not hemolytic. The presence of disulfide bridges and the N-terminal part of its molecule for the structure and antimicrobial activity is essential.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/GA203%2F08%2F0536" target="_blank" >GA203/08/0536: Antimicrobial peptides from insects for possible therapeutic applications</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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