Structural basis for the interaction between carbonic anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F11%3A00365071" target="_blank" >RIV/61388963:_____/11:00365071 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/11:00365071
Result on the web
<a href="http://dx.doi.org/10.1021/jm2000213" target="_blank" >http://dx.doi.org/10.1021/jm2000213</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jm2000213" target="_blank" >10.1021/jm2000213</a>
Alternative languages
Result language
angličtina
Original language name
Structural basis for the interaction between carbonic anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides
Original language description
lsoquinolinesulfonamides inhibit human carbonic anhydrases (hCAs) and display selectivity toward therapeutically relevant isozymes. The crystal structure of hCA 11 in complex with 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamide revealed unusual inhibitor binding. Structural analyses allowed for discerning the fine details of the inhibitor binding mode to the active site, thus providing clues for the future design of even more selective inhibitors for druggable isoforms such as the cancer associated hCA IX and neuronal hCA VII.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA203%2F09%2F0820" target="_blank" >GA203/09/0820: Structure based drug design of specific nucleotidases inhibitors, potentially pharmacologically important compounds.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Medicinal Chemistry
ISSN
0022-2623
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
2522-2526
UT code for WoS article
000289215700048
EID of the result in the Scopus database
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