Efficient synthesis and biological properties of the 2-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F11%3A00369214" target="_blank" >RIV/61388963:_____/11:00369214 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1135/cccc2011105" target="_blank" >http://dx.doi.org/10.1135/cccc2011105</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1135/cccc2011105" target="_blank" >10.1135/cccc2011105</a>

Result language
angličtina
Original language name
Efficient synthesis and biological properties of the 2-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates
Original language description
Efficient synthesis of acyclic nucleosides and acyclic nucleoside phosphonates substituted at the C-2 position of the aliphatic part by the trifluoromethyl group is described, starting from trifluoromethyloxirane. None of the prepared compounds exhibit any antiviral, antiproliferative or anti-toxin activities.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/VG20102015046" target="_blank" >VG20102015046: Targeted drug design for bioterrorism prevention. Development of effective inhibitors of the adenylate cyclase toxin of Bordetella pertusis and Bacillus anthracis.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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