Isolation and Cholinesterase Activity of Amaryllidaceae Alkaloids from Nerine bowdenii

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F11%3A00369375" target="_blank" >RIV/61388963:_____/11:00369375 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/11:10103354

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Isolation and Cholinesterase Activity of Amaryllidaceae Alkaloids from Nerine bowdenii

Original language description

Amaryllidaceae species are known as ornamental plants. Some contain galanthamine, an acetylcholinesterase inhibitor. The chemical composition of the alkaloid extract of bulbs of Nerine bowdenii Watson has been analyzed by means of GC/MS. Twenty-two compounds were detected and nineteen of them identified, one of which was belladine. The alkaloid extract showed promising cholinesterase inhibitory activities against human blood acetylcholinesterase (HuAChE; IC50= 87.9.+-.3.5 .mu.g/mL) and human plasma butyrylcholinesterase (HuBuChE; IC50 = 14.8.+-.1.1 .mu.g/mL). Belladine inhibited HuAChE and HuBuChE in a dose-dependent manner with IC50 values of 781.+-.12.5 .mu.M and 284.84.2 .mu.M, respectively.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Natural Product Communications

ISSN

1934-578X

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

1827-1830

UT code for WoS article

000298445300010

EID of the result in the Scopus database

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