Chemical composition with borane clusters for use as an HIV protease inhibitor
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F11%3A00371074" target="_blank" >RIV/61388963:_____/11:00371074 - isvavai.cz</a>
Alternative codes found
RIV/61388980:_____/11:00371074
Result on the web
<a href="http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8013190.PN.&OS=PN/8013190&RS=PN/8013190" target="_blank" >http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8013190.PN.&OS=PN/8013190&RS=PN/8013190</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Chemical composition with borane clusters for use as an HIV protease inhibitor
Original language description
The present invention provides novel HIV protease inhibitors containing substituted borane, carborane or metallacarborane clusters with 6 to 12 boron atoms in each cluster. The charge of each borane, carborane or metallacarborane cluster is 0, -1 or -2.The number of borane, carborane or metallacarborane clusters in the inhibitor molecule is 1 to 9, and the carborane clusters in metallacarborane inhibitors are coordinated to transition metal atom, selected from the group containing cobalt, iron, nickeland ruthenium. In the cluster, heteroatoms can be present, such as nitrogen, phosphorus, silicon, germanium, tin and sulphur. The present invention covers pharmaceutical compositions containing these inhibitors and their use, both in vitro and in vivo. They are characterized by high effectiveness and stability.
Czech name
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Czech description
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Classification
Type
P - Patent
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Patent/design ID
US8013190
Publisher
US001 -
Publisher name
United States Patent and Trademark Office (USPTO)
Place of publication
Alexandria
Publication country
US - UNITED STATES
Date of acceptance
Sep 6, 2011
Owner name
Ústav organické chemie a biochemie AV ČR, v. v. i. - Vysoká škola chemicko-technologická v Praze - Ústav anorganické chemie AV ČR, v. v. i. - Department of Virology, University of Heidelberg, Heidelberg, DE
Method of use
A - Výsledek využívá pouze poskytovatel
Usage type
A - K využití výsledku jiným subjektem je vždy nutné nabytí licence