Lipid hydration and mobility: An interplay between fluorescence solvent relaxation experiments and molecular dynamics simulations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00375917" target="_blank" >RIV/61388963:_____/12:00375917 - isvavai.cz</a>

Alternative codes found

RIV/61388955:_____/12:00375917

Result on the web

<a href="http://dx.doi.org/10.1016/j.biochi.2011.06.027" target="_blank" >http://dx.doi.org/10.1016/j.biochi.2011.06.027</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biochi.2011.06.027" target="_blank" >10.1016/j.biochi.2011.06.027</a>

Result language

angličtina

Original language name

Lipid hydration and mobility: An interplay between fluorescence solvent relaxation experiments and molecular dynamics simulations

Original language description

Fluorescence solvent relaxation experiments are based on the characterization of time-dependent shifts in the fluorescence emission of a chromophore, yielding polarity and viscosity information about the chromophore's immediate environment. A chromophoreapplied to a phospholipid bilayer at a well-defined location (with respect to the z-axis of the bilayer) allows monitoring of the hydration and mobility of the probed segment of the lipid molecules. Specifically, time-resolved fluorescence experiments,fluorescence quenching data and molecular dynamic (MD) simulations show that 6-lauroyl-2-dimethylaminonaphthalene (Laurdan) probes the hydration and mobility of the sn-1 acyl groups in a phosphatidylcholine bilayer. The time-dependent fluorescence shift(TDFS) of Laurdan provides information on headgroup compression and expansion induced by the addition of different amounts of cationic lipids to phosphatidylcholine bilayers. Those changes were predicted by previous MD simulations. Additi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochimie

ISSN

0300-9084

e-ISSN

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Volume of the periodical

94

Issue of the periodical within the volume

1

Country of publishing house

FR - FRANCE

Number of pages

7

Pages from-to

26-32

UT code for WoS article

000300473200004

EID of the result in the Scopus database

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