Characterization of New Stable Ghrelin Analogs with Prolonged Orexigenic Potency

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00376293" target="_blank" >RIV/61388963:_____/12:00376293 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1124/jpet.111.185371" target="_blank" >http://dx.doi.org/10.1124/jpet.111.185371</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1124/jpet.111.185371" target="_blank" >10.1124/jpet.111.185371</a>

Result language
angličtina
Original language name
Characterization of New Stable Ghrelin Analogs with Prolonged Orexigenic Potency
Original language description
Ghrelin, the only known peripherally produced and centrally acting peptide that stimulates food intake, is synthesized primarily in the stomach and acts through the growth hormone secretagogue receptor (GHS-R1a). In addition to its orexigenic effect, ghrelin stimulates the release of growth hormone (GH). In this study, we investigated the biological properties of full-length and shortened ghrelin analogs in which octanoylated Ser(3) is replaced with an octanoic acid moiety coupled to diaminopropionic acid (Dpr). Ghrelin analogs stabilized with Dpr(N-octanoyl) in position 3 and noncoded amino acids in position 1 (sarcosine) and/or position 4 (naphthylalanine or cyclohexylalanine) were found to possess affinities similar to those of ghrelin for cell membranes with transfected GHS-R1a. In vivo, the prolonged orexigenic effects of analogs containing Dpr(N-octanoyl) 3 compared with that of ghrelin in adult mice and a similar impact on GH secretion in young mice were found. Full-length [Dpr(
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
<a href="/en/project/GA303%2F09%2F0744" target="_blank" >GA303/09/0744: Impact of ghrelin and estrogen on metabolic syndrom of female obese mice</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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