Mutations Conferring Resistance to Viral DNA Polymerase Inhibitors in Camelpox Virus Give Different Drug-Susceptibility Profiles in Vaccinia Virus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00377813" target="_blank" >RIV/61388963:_____/12:00377813 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1128/JVI.00355-12" target="_blank" >http://dx.doi.org/10.1128/JVI.00355-12</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1128/JVI.00355-12" target="_blank" >10.1128/JVI.00355-12</a>

Result language

angličtina

Original language name

Mutations Conferring Resistance to Viral DNA Polymerase Inhibitors in Camelpox Virus Give Different Drug-Susceptibility Profiles in Vaccinia Virus

Original language description

Drug resistance development among orthopoxviruses was studied. Both CMLV and VACV harboring the A314V change showed comparable drug-susceptibility profiles to various antivirals. In contrast, the single change T831I and the double change A314V+A684V in VACV were responsible for increased levels of drug resistance and for cross-resistance to viral DNA polymerase antivirals that were not observed with their CMLV counterparts.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Virology

ISSN

0022-538X

e-ISSN

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Volume of the periodical

86

Issue of the periodical within the volume

13

Country of publishing house

US - UNITED STATES

Number of pages

16

Pages from-to

7310-7325

UT code for WoS article

000305501600029

EID of the result in the Scopus database

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