One-pot build-up procedure for the synthesis of variously substituted purine derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00380853" target="_blank" >RIV/61388963:_____/12:00380853 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/c2ra20842c" target="_blank" >http://dx.doi.org/10.1039/c2ra20842c</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c2ra20842c" target="_blank" >10.1039/c2ra20842c</a>

Result language
angličtina
Original language name
One-pot build-up procedure for the synthesis of variously substituted purine derivatives
Original language description
In this article, we report a one-pot build-up procedure leading to 6-chloro- or 2-amino-6-chloropurines bearing various alkyl or aryl substituents in position N-9. This reaction is simple, fast and effective with up to 96% yields depending on the starting amine. This reaction may be easily combined with further nucleophilic displacement of the C-6 chlorine atom using various reagents, making this procedure very attractive in the field of medicinal chemistry pertaining to compounds based on a purine scaffold.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/VG20102015046" target="_blank" >VG20102015046: Targeted drug design for bioterrorism prevention. Development of effective inhibitors of the adenylate cyclase toxin of Bordetella pertusis and Bacillus anthracis.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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