3 alpha 5 beta-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00381028" target="_blank" >RIV/61388963:_____/12:00381028 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/12:00381028 RIV/00023752:_____/12:43913818
Result on the web
<a href="http://dx.doi.org/10.1016/j.bbr.2012.07.020" target="_blank" >http://dx.doi.org/10.1016/j.bbr.2012.07.020</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbr.2012.07.020" target="_blank" >10.1016/j.bbr.2012.07.020</a>

Result language
angličtina
Original language name
3 alpha 5 beta-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia
Original language description
We have developed novel neuroactive steroid pregnanolone glutamate (3alpfa5beta-P-Glu). 3alpha5beta-P-Glu acts as a use-dependent NMDA receptor antagonist. 3alpha5beta-P-Glu reversed spatial learning deficit in an animal model of schizophrenia. 3alpha5beta-P-Glu did not influence spatial learning of intact animals. 3alpha5beta-P-Glu may represent procognitive drug without side effects
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/NS10365" target="_blank" >NS10365: Biological activity and pharmacokinetic properties of 3?C substituted derivatives of pregnanolone</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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