Pyramidalization of the Glycosidic Nitrogen Provides the Way for Efficient Cleavage of the N-Glycosidic Bond of 8-OxoG with the hOGG1 DNA Repair Protein

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00382846" target="_blank" >RIV/61388963:_____/12:00382846 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/jp309098d" target="_blank" >http://dx.doi.org/10.1021/jp309098d</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jp309098d" target="_blank" >10.1021/jp309098d</a>

Result language
angličtina
Original language name
Pyramidalization of the Glycosidic Nitrogen Provides the Way for Efficient Cleavage of the N-Glycosidic Bond of 8-OxoG with the hOGG1 DNA Repair Protein
Original language description
A mechanistic pathway for cleavage of the N-glycosidic bond of 8-oxo-2-deoxyguanosine (oxoG) catalyzed with the human 8-oxoguanine glycosylase 1 DNA repair protein (hOGG1) is proposed in this theoretical study. The reaction scheme suggests direct protonaddition to the glycosidic nitrogen N9 of oxoG from the N?-ammonium of Lys249 residue of hOGG1 that is enabled owing to the N9 pyramidal geometry. The modification of aromatic character introduced by oxidation to the nucleobase thus seems to be the factor that is checked by hOGG1 to achieve base-specific cleavage.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
—

Project
<a href="/en/project/GAP205%2F10%2F0228" target="_blank" >GAP205/10/0228: Structure and Dynaics of Bioinorganic Complexes</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)