Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00384913" target="_blank" >RIV/61388963:_____/12:00384913 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/12:10124691

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity

Original language description

A new benzyldihydroisoquinoline alkaloid (1) was isolated from the tubers of Corydalis cava and named corylucinine. Additionally, 8-trichloromethyl-7,8-dihydropalmatine (2), an isolation artifact of tetrahydropalmatine, was obtained. The structures wereestablished by spectroscopic (including 2D NMR and optical rotation) and HR-ESI-MS methods. Both compounds were tested for human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBtiChE) inhibitory activity. In comparison withthe used standards, both compounds showed only moderate inhibitory activity against HuAChE (IC50, (HuAChE) = 127.6 +/- 5.2 mu M for 1, and IC50, (HuAchE) = 82.9 +/- 3.9 mu M for 2) and none against HuBuChE.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Natural Product Communications

ISSN

1934-578X

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

2

Pages from-to

859-860

UT code for WoS article

000306764200012

EID of the result in the Scopus database

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