Extent of Intramolecular p-Stacks in Aqueous Solution in Mixed-Ligand Copper(II) Complexes Formed by Heteroaromatic Amines and Several 2-Aminopurine Derivatives of the Antivirally Active Nucleotide Analog 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00385302" target="_blank" >RIV/61388963:_____/12:00385302 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/cbdv.201200022" target="_blank" >http://dx.doi.org/10.1002/cbdv.201200022</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cbdv.201200022" target="_blank" >10.1002/cbdv.201200022</a>

Result language

angličtina

Original language name

Extent of Intramolecular p-Stacks in Aqueous Solution in Mixed-Ligand Copper(II) Complexes Formed by Heteroaromatic Amines and Several 2-Aminopurine Derivatives of the Antivirally Active Nucleotide Analog 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA)

Original language description

The acidity constants of twofold protonated, antivirally active, acyclic nucleoside phosphonates (ANPs), 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), 2-amino-9-[2-(phosphonomethoxy)ethyl]purine (PME2AP), 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP), or 2-amino-6-(dimethylamino)-9-[2-(phosphonomethoxy)ethyl]purine (PME(2A6DMAP), as well as the stability constants of the corresponding ternary Cu complexes are compared. The constants for the systems containing PMEDAP and PME(2A6DMAP) have beendetermined now by potentiometric pH titrations in aqueous solution at I=0.1M (NaNO3) and 25 degrees; the corresponding results for the other ANPs were taken from our earlier work. The basicity of the terminal phosphonate group is very similar for all theANP species, whereas the addition of a second amino substituent at the pyrimidine ring of the purine moiety significantly increases the basicity of the N(1) site. Detailed stability-constant comparisons for mixed-ligand Cu(II) complexes

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/1M0508" target="_blank" >1M0508: New Antivirals and Antineoplastics</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemistry & Biodiversity

ISSN

1612-1872

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

9

Country of publishing house

DE - GERMANY

Number of pages

27

Pages from-to

2008-2034

UT code for WoS article

000308715800032

EID of the result in the Scopus database

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