How insulin engages its primary binding site on the insulin receptor

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00391760" target="_blank" >RIV/61388963:_____/13:00391760 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/nature11781" target="_blank" >http://dx.doi.org/10.1038/nature11781</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/nature11781" target="_blank" >10.1038/nature11781</a>

Result language
angličtina
Original language name
How insulin engages its primary binding site on the insulin receptor
Original language description
Insulin receptor signalling has a central role in mammalian biology, regulating cellular metabolism, growth, division, differentiation and survival. Here we present the first view, to our knowledge, of the interaction of insulin with its primary bindingsite on the insulin receptor, on the basis of four crystal structures of insulin bound to truncated insulin receptor constructs.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
<a href="/en/project/GPP207%2F11%2FP430" target="_blank" >GPP207/11/P430: The role of T- and R-conformations of insulin in binding to the insulin receptor</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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