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Chiral recyclable Cu(II)-catalysts in nitroaldol reaction of aldehydes with various nitroalkanes and its application in the synthesis of a valuable drug (R)-isoproterenol

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00394207" target="_blank" >RIV/61388963:_____/13:00394207 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.apcata.2013.03.032" target="_blank" >http://dx.doi.org/10.1016/j.apcata.2013.03.032</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.apcata.2013.03.032" target="_blank" >10.1016/j.apcata.2013.03.032</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Chiral recyclable Cu(II)-catalysts in nitroaldol reaction of aldehydes with various nitroalkanes and its application in the synthesis of a valuable drug (R)-isoproterenol

  • Original language description

    Chiral dimeric macrocyclic salen ligands 1'a-c and [H-4]salen 2'a-c derived from (1R,2R)-(-)-1,2-diaminocyclohexane, (1R,2R)-(+)-1,2-diphenyl-1,2-diaminoethane, and (R)-(+)-1,1'-binaphthyl-2,2'-diamine with 5,5'-(piperazine-1,4-diylbis(methylene)-bis-(3-tert-butyl-2-hydroxybenzaldehyde) were prepared. Cu(II) complexes 1a-c and 2a-c were generated in situ by the interaction of different source of copper(II) salts with chiral dimeric macrocyclic salen ligands 1'a-c and 2'a-c and used for asymmetric nitroaldol reaction of various aromatic and aliphatic aldehydes with various nitroalkanes at RT (27 +/- 2 degrees C). Excellent yields (98% with respect to the aldehyde) of beta-nitroalcohols with high enantioselectivity (ee, similar to 99%) was achieved in case of 2-fluorobenzaldehyde and nitromethane in ca. 20 h with the use of chiral dinuclear macrocyclic [H4]salen Cu(II)-2'a complex. This protocol also worked well with nitroethane and 2-nitropropane with several aldehydes to furnish the co

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CF - Physical chemistry and theoretical chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Applied Catalysis A - General

  • ISSN

    0926-860X

  • e-ISSN

  • Volume of the periodical

    459

  • Issue of the periodical within the volume

    May

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    9

  • Pages from-to

    97-105

  • UT code for WoS article

    000320477700013

  • EID of the result in the Scopus database