Synthesis, biological evaluation and QSAR study of a series of substituted quinazolines as antimicrobial agents

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00394906" target="_blank" >RIV/61388963:_____/13:00394906 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00044-012-0408-0" target="_blank" >http://dx.doi.org/10.1007/s00044-012-0408-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00044-012-0408-0" target="_blank" >10.1007/s00044-012-0408-0</a>

Result language

angličtina

Original language name

Synthesis, biological evaluation and QSAR study of a series of substituted quinazolines as antimicrobial agents

Original language description

A novel series of 1-N-substituted-3-(4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)urea/thiourea derivatives (6a-6r) and 1-N-substituted-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)urea/thiourea derivatives (14a-14s) were synthesized and screened for antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli. Biological results indicated that the synthesized compounds showed a broad-spectrum activity against tested microorganisms at MIC values between 6.25 and 100 mu g/mL. Compound 6r showed a broad spectrum of activity and was found to be active against all tested species. A quantitative structure-activity relationship study has been carried out on the synthesized compounds to get better insights into pharmacophoric features responsible for the antibacterial activity. Genetic function approximation technique was used to identify descriptors that influence biological

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medicinal Chemistry Research

ISSN

1054-2523

e-ISSN

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Volume of the periodical

22

Issue of the periodical within the volume

9

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

4096-4109

UT code for WoS article

000322181300006

EID of the result in the Scopus database

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