Reversal of the Hofmeister Series: Specific Ion Effects on Peptides

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00395118" target="_blank" >RIV/61388963:_____/13:00395118 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/jp405683s" target="_blank" >http://dx.doi.org/10.1021/jp405683s</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jp405683s" target="_blank" >10.1021/jp405683s</a>

Result language
angličtina
Original language name
Reversal of the Hofmeister Series: Specific Ion Effects on Peptides
Original language description
Ion-specific effects On salting-in and salting-out of proteins, protein denaturation, as well as enzymatic activity are typically rationalized in terms of the Hofmeister Here, we demonstrate by means of NMR spectroscopy and, molecular dynamics simulations that the traditional explanation of the Hofmeister ordering of ions in term of their bulk hydration properties is inadequate. Using triglycine as a model system, we show that the Hofmeister series for anions changes from a direct to a reversed series upon uncapping the N- terminus. Weakly hydrated anions, such as iodide and thio cyanate, interact with the peptide bond; while strongly hydrated anions like sulfate are repelled from it. In Contrast reversed order in interactions, of anions is observed atthe positively charged, uncapped N-terminus, and by analogy, this should also be the case at side chains of positively,Charged amino These results demonstrate that the specific chemical and physical properties, of peptides and proteins p
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Project
<a href="/en/project/GBP208%2F12%2FG016" target="_blank" >GBP208/12/G016: Controlling structure and function of biomolecules at the molecular scale: theory meets experiment</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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