Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00397563" target="_blank" >RIV/61388963:_____/13:00397563 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/13:10144051

Result on the web

<a href="http://dx.doi.org/10.1016/j.tox.2013.07.004" target="_blank" >http://dx.doi.org/10.1016/j.tox.2013.07.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tox.2013.07.004" target="_blank" >10.1016/j.tox.2013.07.004</a>

Result language

angličtina

Original language name

Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates

Original language description

Acyclic nucleoside phosphonates (ANPs) possess antiviral and antiproliferative activities. This study investigated in vitro relationships between the affinity of several structurally related potent ANPs to selected human transporters and their cytotoxicity. SLC (solute carrier family) transporters (hOAT1, hOCT2, hCNT2, hCNT3) and ABC (ATP-binding cassette) transporters (MDR1, BCRP), which are typically expressed in the kidney, were included in the study. Most of the ANPs studied showed the potency to interact with hOAT1 and GS-9191, a double prodrug of PMEG, displayed an affinity for hOAT1 comparable with that of adefovir and tenofovir. The study documented that among the studied transporters hOAT1 seems to be the decisive determinant for renal handling in most of the tested ANPs. This transporter may also play an important role in the mechanism of their potential cytotoxic effects.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/NT12398" target="_blank" >NT12398: Study on relationships between toxicity and transport mechanism of antivirals</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology

ISSN

0300-483X

e-ISSN

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Volume of the periodical

311

Issue of the periodical within the volume

3

Country of publishing house

IE - IRELAND

Number of pages

12

Pages from-to

135-146

UT code for WoS article

000324609200006

EID of the result in the Scopus database

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