Effect of 8-Oxoguanine on DNA Structure and Deformability
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00399993" target="_blank" >RIV/61388963:_____/13:00399993 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/jp407562t" target="_blank" >http://dx.doi.org/10.1021/jp407562t</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jp407562t" target="_blank" >10.1021/jp407562t</a>
Alternative languages
Result language
angličtina
Original language name
Effect of 8-Oxoguanine on DNA Structure and Deformability
Original language description
8-Oxoguanine (oxoG) is an abundant product of oxidative DNA damage. It is removed by repair glycosylases, but exactly how the enzymes recognize oxoG in the large surplus of undamaged bases is not fully understood. The lesion may induce changes in the properties of naked DNA that facilitate the recognition. In this work, we assess the effect of oxoG on DNA structure and mechanical deformability. We performed extensive unrestrained, atomic resolution molecular dynamics simulations to parametrize a nonlocal, rigid base mechanical model of DNA. Our data indicate that oxoG induces unwinding of the base pair step at the 5'-side of the lesion. This brings the damaged DNA closer to its conformation in the initial complex with bacterial glycosylase MutM. The untwisting is partially caused by different BII substate populations and is further enhanced by the base-sugar repulsion within oxoG. On the other hand, our analysis shows that damaged and undamaged DNA have very similar harmonic stiffness.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Physical Chemistry B
ISSN
1520-6106
e-ISSN
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Volume of the periodical
117
Issue of the periodical within the volume
39
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
11617-11622
UT code for WoS article
000326301000022
EID of the result in the Scopus database
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