Synthesis of enantiopure drugs and drug intermediates by immobilized lipase-catalysis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00424054" target="_blank" >RIV/61388963:_____/13:00424054 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.2174/22115528112019990009" target="_blank" >http://dx.doi.org/10.2174/22115528112019990009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/22115528112019990009" target="_blank" >10.2174/22115528112019990009</a>

Result language

angličtina

Original language name

Synthesis of enantiopure drugs and drug intermediates by immobilized lipase-catalysis

Original language description

Enantiomerically pure product synthesis plays a key role in production of pharmaceuticals. The application of biocatalytic approaches represents a convenient and sustainable way for this purpose. The enormous potential of enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivity is on increasing awareness. In particular, lipases show a high versatility to recognize non-natural substrates being successfully applied in regio- and stereoselective biotransformations. The immobilization technology on lipases is not only a requisite for the industrial implementation but it has been a great methodology to alter their catalytic properties to obtain highly enantio- and regiose-lective biocatalysts in the enantioselective synthesis of chiral drugs or drug intermediates. This review focuses on showing some of the latest advances on the use of immobilized lipases on pharmaceutical biotransformations.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Bioactive Compounds

ISSN

1573-4072

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

24

Pages from-to

113-136

UT code for WoS article

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EID of the result in the Scopus database

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