How well does cholesteryl hemisuccinate mimic cholesterol in saturated phospholipid bilayers?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00427717" target="_blank" >RIV/61388963:_____/14:00427717 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00894-014-2121-z" target="_blank" >http://dx.doi.org/10.1007/s00894-014-2121-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00894-014-2121-z" target="_blank" >10.1007/s00894-014-2121-z</a>
Alternative languages
Result language
angličtina
Original language name
How well does cholesteryl hemisuccinate mimic cholesterol in saturated phospholipid bilayers?
Original language description
Cholesteryl hemisuccinate is a detergent that is often used to replace cholesterol in crystallization of membrane proteins. Here we employ atomistic molecular dynamics simulations to characterize how well the properties of cholesteryl hemisuccinate actually match those of cholesterol in saturated protein-free lipid membranes. We show that the protonated form of cholesteryl hemisuccinate mimics many of the membrane properties of cholesterol quite well, while the deprotonated form of cholesteryl hemisuccinate is less convincing in this respect. Based on the results, we suggest that cholesteryl hemisuccinate in its protonated form is a quite faithful mimic of cholesterol for membrane protein crystallization, if specific cholesterol-protein interactions (not investigated here) are not playing a crucial role.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP208%2F12%2FG016" target="_blank" >GBP208/12/G016: Controlling structure and function of biomolecules at the molecular scale: theory meets experiment</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Molecular Modeling
ISSN
1610-2940
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
9
Pages from-to
"2121/1"-"2121/9"
UT code for WoS article
000332179000023
EID of the result in the Scopus database
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