Pyrrolidine nucleotide analogs with a tunable conformation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00431792" target="_blank" >RIV/61388963:_____/14:00431792 - isvavai.cz</a>
Result on the web
<a href="http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-10-205" target="_blank" >http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-10-205</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3762/bjoc.10.205" target="_blank" >10.3762/bjoc.10.205</a>

Result language
angličtina
Original language name
Pyrrolidine nucleotide analogs with a tunable conformation
Original language description
Conformational preferences of the pyrrolidine ring in nucleotide analogs 7-14 were investigated by means of NMR and molecular modeling. The effect of the relative configuration of hydroxy and nucleobase substituents as well as the effect of the alkylation or acylation of the pyrrolidine nitrogen atom on the conformation of the pyrrolidine ring were studied. The results of a conformational analysis show that the alkylation/acylation can be effectively used for tuning the pyrrolidine conformation over thewhole pseudorotation cycle.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/GA13-24880S" target="_blank" >GA13-24880S: Structure and Properties of Modified Components of Nucleic Acids</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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