Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00433963" target="_blank" >RIV/61388963:_____/14:00433963 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/1471-2202-15-111" target="_blank" >http://dx.doi.org/10.1186/1471-2202-15-111</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1471-2202-15-111" target="_blank" >10.1186/1471-2202-15-111</a>

Result language

angličtina

Original language name

Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats

Original language description

Background: Insulin signaling and Tau protein phosphorylation in the hippocampi of young and old obese Zucker fa/fa rats and their lean controls were assessed to determine whether obesity-induced peripheral insulin resistance and aging are risk factors for central insulin resistance and whether central insulin resistance is related to the pathologic phosphorylation of the Tau protein. Results: Aging and obesity significantly attenuated the phosphorylation of the insulin cascade kinases Akt (protein kinase B, PKB) and GSK-3 beta (glycogen synthase kinase 3 beta) in the hippocampi of the fa/fa rats. Furthermore, the hyperphosphorylation of Tau Ser396 alone and both Tau Ser396 and Thr231 was significantly augmented by aging and obesity, respectively, in the hippocampi of these rats. Conclusions: Both age-induced and obesity-induced peripheral insulin resistance are associated with central insulin resistance that is linked to hyperTau phosphorylation. Peripheral hyperinsulinemia, rather th

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Neuroscience

ISSN

1471-2202

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

Sep 25

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

"111/1"-"111/8"

UT code for WoS article

000342367600001

EID of the result in the Scopus database

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