Interaction of L-Phenylalanine with a Phospholipid Monolayer at the WaterAir Interface

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00446772" target="_blank" >RIV/61388963:_____/15:00446772 - isvavai.cz</a>
Alternative codes found
RIV/61388955:_____/15:00446772
Result on the web
<a href="http://dx.doi.org/10.1021/jp508473w" target="_blank" >http://dx.doi.org/10.1021/jp508473w</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jp508473w" target="_blank" >10.1021/jp508473w</a>

Result language
angličtina
Original language name
Interaction of L-Phenylalanine with a Phospholipid Monolayer at the WaterAir Interface
Original language description
The interaction of L-phenylalanine with a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayer at the air-water interface was explored using a combination of experimental techniques and molecular dynamics (MD) simulations. By means of Langmuir trough methods and Brewster angle microscopy, L-phenylalanine was shown to significantly alter the interfacial tension and the surface domain morphology of the DPPC film. In addition, confocal microscopy was used to explore the aggregation state of L-phenylalanine in the bulk aqueous phase. Finally, MD simulations were performed to gain molecular-level information on the interactions of L-phenylalanine and DPPC at the interface. Taken together, these results show that L-phenylalanine intercalates into a DPPC film at the air-water interface, thereby affecting the surface tension, phase morphology, and ordering of the DPPC film. The results are discussed in the context of biological systems and the mechanism of diseases such as phenylketonu
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Project
<a href="/en/project/GA13-06181S" target="_blank" >GA13-06181S: Investigation of lipid Langmuir monolayers interacting with atmospheric oxidants and pollutants by molecular simulations</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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