Synthesis of Fluorescent 2-Substituted 6-(Het)aryl-7-deazapurine Bases {4-(Het)aryl-pyrrolo[2,3-d]pyrimidines} by Aqueous Suzuki-Miyaura Cross-Coupling Reactions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F16%3A00459237" target="_blank" >RIV/61388963:_____/16:00459237 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/16:10336657
Result on the web
<a href="http://dx.doi.org/10.1055/s-0035-1561287" target="_blank" >http://dx.doi.org/10.1055/s-0035-1561287</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1055/s-0035-1561287" target="_blank" >10.1055/s-0035-1561287</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis of Fluorescent 2-Substituted 6-(Het)aryl-7-deazapurine Bases {4-(Het)aryl-pyrrolo[2,3-d]pyrimidines} by Aqueous Suzuki-Miyaura Cross-Coupling Reactions
Original language description
A series of 4-(het)aryl-pyrrolo[2,3-d]pyrimidines [6-(het)aryl-7-deazapurine bases] bearing a H, NH2, CH3, F, or Cl group at the 2-position and either H or F at the 5-position (position 7 of 7-deazapurine) were prepared in a single step by the aqueous Suzuki-Miyaura cross-coupling reactions of the corresponding 6-chloro-7-deazapurines with (het)arylboronic acids. Unlike their ribonucleoside derivatives, which are potent cytostatics, the deazapurine bases did not show significant biological activity but most of them exerted bright fluorescence with emission maxima 368-468 nm and high quantum yields up to 0.83.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Synthesis
ISSN
0039-7881
e-ISSN
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Volume of the periodical
48
Issue of the periodical within the volume
7
Country of publishing house
DE - GERMANY
Number of pages
17
Pages from-to
1029-1045
UT code for WoS article
000372882200013
EID of the result in the Scopus database
2-s2.0-84962607150