A Modular Synthesis of N-Benzotriazole Ureas Using Alkylation of 5-Nitrobenzotriazole
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F16%3A00469894" target="_blank" >RIV/61388963:_____/16:00469894 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/16:10324183
Result on the web
<a href="http://dx.doi.org/10.1002/slct.201600025" target="_blank" >http://dx.doi.org/10.1002/slct.201600025</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/slct.201600025" target="_blank" >10.1002/slct.201600025</a>
Alternative languages
Result language
angličtina
Original language name
A Modular Synthesis of N-Benzotriazole Ureas Using Alkylation of 5-Nitrobenzotriazole
Original language description
N-Alkylations of monosubstituted benzotriazoles yield isomeric products with distinct topology, i.e. 1H- or to 2H- isomers. Therefore, the molecular shape of these compounds varies and this results in distinct biological and physical properties. Herein, a protocol for the simple synthesis of various alkyl-aminobenzotriazoles using 5-nitrobenzotriazole is reported. This synthetic approach furnishes 2-alkyl-5-nitro-2H-benzotriazoles as major products in most of the attempted cases. All three obtained isomers were separable from each other by standard column chromatography. In addition, three alternative approaches furnishing selectively substituted alkyl-amino-1H-benzotriazoles are described. Finally, a library of sixty-eight N-benzotriazoylureas and six N-benzotriazoylthioureas was synthesized by reactions with either isocyanates (phenyl chloroformate) or isothiocyanates.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GA13-19561S" target="_blank" >GA13-19561S: Design, characterization and mechanism of action of novel inhibitors of HIV assembly</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemistrySelect
ISSN
2365-6549
e-ISSN
—
Volume of the periodical
1
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
101-107
UT code for WoS article
000392410300016
EID of the result in the Scopus database
—