Non-canonical transcription initiation: the expanding universe of transcription initiating substrates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00474811" target="_blank" >RIV/61388963:_____/17:00474811 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/17:00474811 RIV/00216208:11320/17:10370902
Result on the web
<a href="http://dx.doi.org/10.1093/femsre/fuw041" target="_blank" >http://dx.doi.org/10.1093/femsre/fuw041</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/femsre/fuw041" target="_blank" >10.1093/femsre/fuw041</a>
Alternative languages
Result language
angličtina
Original language name
Non-canonical transcription initiation: the expanding universe of transcription initiating substrates
Original language description
RNA polymerase (RNAP) is the central enzyme of transcription of the genetic information from DNA into RNA. RNAP recognizes four main substrates: ATP, CTP, GTP and UTP. Experimental evidence from the past several years suggests that, besides these four NTPs, other molecules can be used to initiate transcription: (i) ribooligonucleotides (nanoRNAs) and (ii) coenzymes such as NAD(+), NADH, dephospho-CoA and FAD. The presence of these molecules at the 5' ends of RNAs affects the properties of the RNA. Here, we discuss the expanding portfolio of molecules that can initiate transcription, their mechanism of incorporation, effects on RNA and cellular processes, and we present an outlook toward other possible initiation substrates.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FEMS Microbiology Reviews
ISSN
0168-6445
e-ISSN
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Volume of the periodical
41
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
131-138
UT code for WoS article
000396366700002
EID of the result in the Scopus database
2-s2.0-85016220107