Azidoperfluoroalkanes: Synthesis and Application in Copper(I)-Catalyzed Azide-Alkyne Cycloaddition

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00474969" target="_blank" >RIV/61388963:_____/17:00474969 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/anie.201609715/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/anie.201609715/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/anie.201609715" target="_blank" >10.1002/anie.201609715</a>

Result language
angličtina
Original language name
Azidoperfluoroalkanes: Synthesis and Application in Copper(I)-Catalyzed Azide-Alkyne Cycloaddition
Original language description
We report an efficient and scalable synthesis of azidotrifluoromethane (CF3N3) and longer perfluorocarbonchain analogues (RFN3, R-F= C2F5, (C3F7)-C-n, (C8F17)-C-n), which enables the direct insertion of CF3 and perfluoroalkyl groups into triazole ring systems. The azidoperfluoroalkanes show good reactivity with terminal alkynes in copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), giving access to rare and stable N-perfluoroalkyl triazoles. Azidoperfluoroalkanes are thermally stable and the efficiency of their preparation should be attractive for discovery programs.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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