Retargeting Polyomavirus-Like Particles to Cancer Cells by Chemical Modification of Capsid Surface
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00475080" target="_blank" >RIV/61388963:_____/17:00475080 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/17:10338126 RIV/00216208:11310/17:10338126
Result on the web
<a href="http://dx.doi.org/10.1021/acs.bioconjchem.6b00622" target="_blank" >http://dx.doi.org/10.1021/acs.bioconjchem.6b00622</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.bioconjchem.6b00622" target="_blank" >10.1021/acs.bioconjchem.6b00622</a>
Alternative languages
Result language
angličtina
Original language name
Retargeting Polyomavirus-Like Particles to Cancer Cells by Chemical Modification of Capsid Surface
Original language description
Virus-like particles based on polyomaviruses (PVLPs) are promising delivery devices for various cargoes, including nucleic acids, imaging probes, and therapeutic agents. In biological environments, the major coat protein VP1 interacts with ubiquitously distributed sialic acid residues, and therefore PVLPs show a broad tropism. For selective targeting, appropriate engineering of the PVLP surface is needed. Here, we describe a chemical approach to retarget PVLPs to cancer cells displaying abnormally high levels of transferrin receptor. We created an array of transferrin molecules on the surface of PVLPs by combining a high-yielding bioconjugation approach with specific point modification of transferrin. This artificial surface protein architecture enables (i) suppression of natural VP1-specific interactions by blocking the surface conformational epitope on the VP1 protein, (ii) unusually high cellular uptake efficiency, and (iii) selective retargeting of PVLPs to osteosarcoma (U2OS) and lymphoblastoid leukemia (CCRF-CEM) cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioconjugate Chemistry
ISSN
1043-1802
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
307-313
UT code for WoS article
000394481700006
EID of the result in the Scopus database
2-s2.0-85013131002