Co-option of the sphingolipid metabolism for the production of nitroalkene defensive chemicals in termite soldiers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00475221" target="_blank" >RIV/61388963:_____/17:00475221 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/17:00475221
Result on the web
<a href="http://dx.doi.org/10.1016/j.ibmb.2017.01.008" target="_blank" >http://dx.doi.org/10.1016/j.ibmb.2017.01.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ibmb.2017.01.008" target="_blank" >10.1016/j.ibmb.2017.01.008</a>
Alternative languages
Result language
angličtina
Original language name
Co-option of the sphingolipid metabolism for the production of nitroalkene defensive chemicals in termite soldiers
Original language description
The aliphatic nitroalkene (E)-1-nitropentadec-1-ene (NPD), reported in early seventies in soldiers of the termite genus Prorhinotermes, was the first documented nitro compound produced by insects. Yet, its biosynthetic origin has long remained unknown. Our observations provide a strong support to a biosynthetic scenario of NPD formation, representing an analogy of the sphingolipid pathway starting with the condensation of tetradecanoic acid with L-serine and leading to the formation of a C16 sphinganine. The proposed biosynthetic sequence has been constructed from age-related quantitative dynamics of individual intermediates and confirmed by the detection of labeled products downstream of the administered intermediates. Comparative RNA-Seq analyses followed by qRT-PCR validation identified orthologs of serine palmitoyltransferase and 3-ketodihydrosphingosine reductase genes as highly expressed in the NPD productionnsite.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GP13-25137P" target="_blank" >GP13-25137P: Biogenesis of (E)-1-nitropentadec-1-ene in soldiers of the termite genus Prorhinotermes</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Insect Biochemistry and Molecular Biology
ISSN
0965-1748
e-ISSN
—
Volume of the periodical
82
Issue of the periodical within the volume
Mar
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
52-61
UT code for WoS article
000397361500006
EID of the result in the Scopus database
2-s2.0-85011932304