Determination of selected bisphenols, parabens and estrogens in human plasma using LC-MS/MS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00477766" target="_blank" >RIV/61388963:_____/17:00477766 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/17:00477766 RIV/61383082:_____/17:00000376 RIV/00216208:11110/17:10368056 RIV/00023761:_____/17:N0000017
Result on the web
<a href="http://dx.doi.org/10.1016/j.talanta.2017.05.070" target="_blank" >http://dx.doi.org/10.1016/j.talanta.2017.05.070</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.talanta.2017.05.070" target="_blank" >10.1016/j.talanta.2017.05.070</a>
Alternative languages
Result language
angličtina
Original language name
Determination of selected bisphenols, parabens and estrogens in human plasma using LC-MS/MS
Original language description
In this study, a novel liquid chromatography tandem mass spectrometry method for the simultaneous determination of bisphenols (BPA, BPS, BPF, BPAF), parabens (methyl-, ethyl-, propyl-, butyl-, benzyl-paraben) and estrogens (estrone, estradiol, estriol) in human plasma is presented. Since all analytes possess the phenolic group, dansyl chloride derivatization was applied in order to gain high sensitivity. The method was validated according to FDA guidelines, and all validation requirements were satisfactory. The lower limits of quantifications were 41.6, 54.9, 43.5 and 150.8 pg/mL for BPA, BPS, BPF and BPAF, 172, 149, 171, 134 and 202 pg/mL for methyl-, ethyl-, propyl-, butyl- and benzyl-paraben, 10.5, 6.7 and 9.4 pg/mL for estrone, estradiol and estriol, respectively. This is the first method allowing the determination of plasma bisphenols, parabens and estrogens in one run, and also the first determination of BPF levels in human plasma. The method was used to examine the plasma levels of healthy normospermic men, where three times higher plasma levels of BPF than BPA were found.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Talanta
ISSN
0039-9140
e-ISSN
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Volume of the periodical
174
Issue of the periodical within the volume
NOV 1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
21-28
UT code for WoS article
000407524900004
EID of the result in the Scopus database
2-s2.0-85019970353