Trifluoroacetophenone-Linked Nucleotides and DNA for Studying of DNA-Protein Interactions by F-19 NMR Spectroscopy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00482591" target="_blank" >RIV/61388963:_____/17:00482591 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/17:10365529
Result on the web
<a href="http://dx.doi.org/10.1021/acs.joc.7b01920" target="_blank" >http://dx.doi.org/10.1021/acs.joc.7b01920</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.joc.7b01920" target="_blank" >10.1021/acs.joc.7b01920</a>
Alternative languages
Result language
angličtina
Original language name
Trifluoroacetophenone-Linked Nucleotides and DNA for Studying of DNA-Protein Interactions by F-19 NMR Spectroscopy
Original language description
A series of 7-[4-(trifluoroacetyl)phenyl]-7-deazaadenine and -7-deazaguanine as well as 5-substituted uracil and cytosine 2'-deoxyribonudeosides and mono- and triphosphates were synthesized through aqueous Suzuki-Miyaura crosscoupling of halogenated nucleosides or nucleotides with 4-(trifluoroacetyl)phenylboronic acid. The modified nucleoside triphosphates were good substrates for DNA polymerases applicable in primer extension or PCR synthesis of modified oligonucleotides or DNA. Attempted cross-linking with a serine-containing protein did not proceed, however the trifluoroacetophenone group was a sensitive probe for the study of DNA protein interactions by F-19 NMR.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/GBP206%2F12%2FG151" target="_blank" >GBP206/12/G151: Center of novel approaches to bioanalysis and molecular diagnostics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Organic Chemistry
ISSN
0022-3263
e-ISSN
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Volume of the periodical
82
Issue of the periodical within the volume
21
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
11431-11439
UT code for WoS article
000414724000012
EID of the result in the Scopus database
2-s2.0-85032824275