Mechanism and Inhibition of Rhomboid Proteases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00483415" target="_blank" >RIV/61388963:_____/17:00483415 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/bs.mie.2016.10.014" target="_blank" >http://dx.doi.org/10.1016/bs.mie.2016.10.014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/bs.mie.2016.10.014" target="_blank" >10.1016/bs.mie.2016.10.014</a>

Result language
angličtina
Original language name
Mechanism and Inhibition of Rhomboid Proteases
Original language description
Intramembrane serine proteases of the rhomboid family are widespread, and their gradually uncovered functions in different organisms already suggest medical relevance for infectious diseases and cancer. However, selective inhibitors that could serve as research tools for rhomboids, for validation of their disease relevance, or as templates for drug development are lacking. Here I summarize the current knowledge about rhomboid protease mechanism and specificity, overview the currently used inhibitors, and conclude by proposing avenues for future development of rhomboid protease inhibitors.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Enzymology at the Membrane Interface: Intramembrane Proteases
ISBN
978-0-12-812213-6
Number of pages of the result
15
Pages from-to
279-293
Number of pages of the book
474
Publisher name
Academic Press
Place of publication
Cambridge
UT code for WoS chapter
000403271000012

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