Phencyclidine Discoordinates Hippocampal Network Activity But Not Place Fields

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00484238" target="_blank" >RIV/61388963:_____/17:00484238 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/17:00487929 RIV/00023752:_____/17:43919162

Result on the web

<a href="http://dx.doi.org/10.1523/JNEUROSCI.0630-17.2017" target="_blank" >http://dx.doi.org/10.1523/JNEUROSCI.0630-17.2017</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1523/JNEUROSCI.0630-17.2017" target="_blank" >10.1523/JNEUROSCI.0630-17.2017</a>

Result language

angličtina

Original language name

Phencyclidine Discoordinates Hippocampal Network Activity But Not Place Fields

Original language description

We used the psychotomimetic phencyclidine (PCP) to investigate the relationships among cognitive behavior, coordinated neural network function, and information processing within the hippocampus place cell system. We report in rats that PCP (5 mg/kg, i.p.) impairs a well learned, hippocampus-dependent place avoidance behavior in rats that requires cognitive control even when PCP is injected directly into dorsal hippocampus. PCP increases 60-100 Hz medium-freguency gamma oscillations in hippocampus CA1 and these increases correlate with the cognitive impairment caused by systemic PCP administration. PCP discoordinates theta-modulated medium-frequency and slow gamma oscillations in CA1 LFPs such that medium-frequency gamma oscillations become more theta-organized than slow gamma oscillations. CA1 place cell firing fields are preserved under PCP, but the drug discoordinates the subsecond temporal organization of discharge among place cells. This discoordination causes place cell ensemble representations of a familiar space to cease resembling pre-PCP representations despite preserved place fields. These findings point to the cognitive impairments caused by PCP arising from neural discoordination. PCP disrupts the timing of discharge with respect to the subsecond timescales of theta and gamma oscillations in the LFP. Because these oscillations arise from local inhibitory synaptic activity, these findings point to excitation-inhibition discoordination as the root of PCP-induced cognitive impairment.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neuroscience

ISSN

0270-6474

e-ISSN

—

Volume of the periodical

37

Issue of the periodical within the volume

49

Country of publishing house

US - UNITED STATES

Number of pages

19

Pages from-to

12031-12049

UT code for WoS article

000418053700020

EID of the result in the Scopus database

2-s2.0-85037670928