Nucleoside-O-Methyl-(H)-Phosphinates: Novel Monomers for the Synthesis of Methylphosphonate Oligonucleotides Using H-Phosphonate Chemistry

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00485551" target="_blank" >RIV/61388963:_____/17:00485551 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/cpnc.35" target="_blank" >http://dx.doi.org/10.1002/cpnc.35</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cpnc.35" target="_blank" >10.1002/cpnc.35</a>

Result language
angličtina
Original language name
Nucleoside-O-Methyl-(H)-Phosphinates: Novel Monomers for the Synthesis of Methylphosphonate Oligonucleotides Using H-Phosphonate Chemistry
Original language description
This unit comprises the straightforward synthesis of protected 2´- deoxyribonucleoside-O-methyl-(H)-phosphinates in both 3´- and 5´-series. These compounds represent a newclass of monomers compatible with the solidphase synthesis of oligonucleotides using H-phosphonate chemistry and are suitable for the preparation of both 3´- and 5´-O-methylphosphonate oligonucleotides. The synthesis of 4-toluenesulfonyloxymethyl-(H)-phosphinic acid as a new reagent for the preparation of O-methyl-(H)-phosphinic acid derivatives is described.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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