Profiling system for skin kallikrein proteolysis applied in gene-deficient mouse models

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00492934" target="_blank" >RIV/61388963:_____/18:00492934 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/18:00492934 RIV/00216208:11310/18:10377693
Result on the web
<a href="http://dx.doi.org/10.1515/hsz-2018-0116" target="_blank" >http://dx.doi.org/10.1515/hsz-2018-0116</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/hsz-2018-0116" target="_blank" >10.1515/hsz-2018-0116</a>

Result language
angličtina
Original language name
Profiling system for skin kallikrein proteolysis applied in gene-deficient mouse models
Original language description
Kallikrein-related proteases (KLKs) play a critical role in epidermis physiology and have been implicated in skin pathologies such as Netherton syndrome. The contribution of individual KLKs to skin proteolysis is poorly understood. Monitoring of their activities in skin proteome is hampered by overlapping substrate specificities, and there is a need for novel assays. Here, we present a platform of selective and sensitive fluorogenic substrates and inhibitors for profiling KLK5, KLK7 and KLK14. These chemical tools were evaluated using recombinant KLKs and tissue from a unique set of mice deficient in eight combinations of KLKs and their natural regulator LEKTI.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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