The Rhomboid Superfamily: Structural Mechanisms and Chemical Biology Opportunities
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00493058" target="_blank" >RIV/61388963:_____/18:00493058 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/18:10378708
Result on the web
<a href="http://dx.doi.org/10.1016/j.tibs.2018.06.009" target="_blank" >http://dx.doi.org/10.1016/j.tibs.2018.06.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tibs.2018.06.009" target="_blank" >10.1016/j.tibs.2018.06.009</a>
Alternative languages
Result language
angličtina
Original language name
The Rhomboid Superfamily: Structural Mechanisms and Chemical Biology Opportunities
Original language description
The rhomboid superfamily of transmembrane (TM) proteins includes intramembrane serine proteases and several classes of pseudoprotease. Rhomboid-like proteins occur widely across evolution and comprise biologically important regulators of fate of membrane proteins, influencing their proteolysis, trafficking, or degradation. In this review, we discuss how structural and mechanistic insights into the action of rhomboid proteases can inform on the mechanism of the pseudoproteases, and discuss the impact of structural understanding on the development of inhibitors and other chemical biology tools for these proteins. Development of modulators would be particularly relevant for the iRhoms, which are key regulators of ADAM17 and, hence, tumor necrosis factor (TNF) and epidermal growth factor receptor (EGFR) signaling, two medically important pathways.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Trends in Biochemical Sciences
ISSN
0968-0004
e-ISSN
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Volume of the periodical
43
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
726-739
UT code for WoS article
000442165600008
EID of the result in the Scopus database
2-s2.0-85050338725