Widespread evolutionary crosstalk among protein domains in the context of multi- domain proteins
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00493595" target="_blank" >RIV/61388963:_____/18:00493595 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11320/18:10377763 RIV/00216208:11310/18:10377763
Result on the web
<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203085" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203085</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0203085" target="_blank" >10.1371/journal.pone.0203085</a>
Alternative languages
Result language
angličtina
Original language name
Widespread evolutionary crosstalk among protein domains in the context of multi- domain proteins
Original language description
Domains are distinct units within proteins that typically can fold independently into recognizable three-dimensional structures to facilitate their functions. The structural and functional independence of protein domains is reflected by their apparent modularity in the context of multi-domain proteins. In this work, we examined the coupling of evolution of domain sequences co-occurring within multi-domain proteins to see if it proceeds independently, or in a coordinated manner. We used continuous information theory measures to assess the extent of correlated mutations among domains in multi-domain proteins from organisms across the tree of life. In all multi-domain architectures we examined, domains co-occurring within protein sequences had to some degree undergone concerted evolution. This finding challenges the notion of complete modularity and independence of protein domains, providing new perspective on the evolution of protein sequence and function.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/LM2015047" target="_blank" >LM2015047: Czech National Infrastructure for Biological Data</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
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UT code for WoS article
000443374400020
EID of the result in the Scopus database
2-s2.0-85052993774