Thienopyrrolo[2, 3-d]pyrimidines, New Tricyclic Nucleobase Analogues: Synthesis and Biological Activities
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00493609" target="_blank" >RIV/61388963:_____/18:00493609 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/18:10383273
Result on the web
<a href="http://dx.doi.org/10.1002/slct.201802190" target="_blank" >http://dx.doi.org/10.1002/slct.201802190</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/slct.201802190" target="_blank" >10.1002/slct.201802190</a>
Alternative languages
Result language
angličtina
Original language name
Thienopyrrolo[2, 3-d]pyrimidines, New Tricyclic Nucleobase Analogues: Synthesis and Biological Activities
Original language description
Three isomeric series of 4-substituted thieno-fused 7-deazapurine nucleobases were synthesized by palladium catalyzed couplings or nucleophilic substitutions from protected key-intermediate 4-chlorothienopyrrolopyrimidines. Most final nucleobases exerted micromolar activity against hepatitis C virus and respiratory syncytial virus, as well as some in vitro cytostatic activities against several cancer and leukemia cell lines. Three new nucleosides derived from 8H-thieno[3',4':4,5]pyrrolo[2,3-d] pyrimidine were also synthesized and were significantly more cytostatic than corresponding nucleobases, with activities in submicromolar range and low toxicity to normal cycling fibroblasts.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/GA16-00178S" target="_blank" >GA16-00178S: Novel nucleosides and nucleotides derived from hetero-fused 7-deazapurines</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemistrySelect
ISSN
2365-6549
e-ISSN
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Volume of the periodical
3
Issue of the periodical within the volume
31
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
9144-9149
UT code for WoS article
000442985800049
EID of the result in the Scopus database
2-s2.0-85052606083