Targeting Glioma Cancer Cells with Fluorescent Nanodiamonds via Integrin Receptors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00494902" target="_blank" >RIV/61388963:_____/18:00494902 - isvavai.cz</a>
Alternative codes found
RIV/61389005:_____/18:00494902 RIV/61389013:_____/18:00494902
Result on the web
<a href="http://dx.doi.org/10.1007/7653_2017_68" target="_blank" >http://dx.doi.org/10.1007/7653_2017_68</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/7653_2017_68" target="_blank" >10.1007/7653_2017_68</a>

Result language
angličtina
Original language name
Targeting Glioma Cancer Cells with Fluorescent Nanodiamonds via Integrin Receptors
Original language description
Glioblastomas, aggressive and highly vascularized brain tumors, overexpress αvβ3 integrins, which are widely exploited for cancer diagnostics and therapy. Proteins and peptides containing the RGD sequence bind αvβ3 integrins. Here, we describe detailed protocols for preparation and testing of fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell. When the surface of these particles was modified with a cyclic RGD peptide, they selectively targeted integrin αvβ3 receptors on U-87 MG glioblastoma cells with high internalization efficacy. The modified particles enabled background-free near-infrared imaging of cells, showed excellent colloidal stability in culture media, and exhibited negligible cytotoxicity.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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