Insulin derivative with cyclic structure in the C-terminus of the B-chain

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00499715" target="_blank" >RIV/61388963:_____/18:00499715 - isvavai.cz</a>
Result on the web
<a href="https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=EP&NR=3160993B1&KC=B1&FT=D&ND=4&date=20180627&DB=&locale=en_EP#" target="_blank" >https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=EP&NR=3160993B1&KC=B1&FT=D&ND=4&date=20180627&DB=&locale=en_EP#</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Insulin derivative with cyclic structure in the C-terminus of the B-chain
Original language description
The present invention relates to an insulin derivative of formula I, consisting of des(B23-B30)octapeptide-insulin (DOI) and a modified octapeptide, which form an amide bond between the carboxyl group of C-terminal ArgB22 in the DOI molecule and the amino group of N-terminal GlyB23 in the molecule of the modified octapeptide comprising a cyclic structure. The des(B23-B30)octapeptide-insulin is human insulin without the C-terminal octapeptide B23-30 and the modified octapeptide imitates the B23-B30 sequence of human insulin. The insulin derivative of formula I is suitable for use as an anti-diabetic agent with a fast onset of action and low risk of cancer propagation.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Patent/design ID
EP3160993
Publisher
EPO_1 -
Publisher name
European Patent Office
Place of publication
Munich, The Hague, Berlin, Vienna, Brussels
Publication country
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Date of acceptance
Jun 27, 2018
Owner name
Ústav organické chemie a biochemie AV ČR, v. v. i. - The University of York
Method of use
A - Výsledek využívá pouze poskytovatel
Usage type
A - K využití výsledku jiným subjektem je vždy nutné nabytí licence

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