The impact of anorexigenic peptides in experimental models of Alzheimer's disease pathology

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00501595" target="_blank" >RIV/61388963:_____/19:00501595 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/19:00504220
Result on the web
<a href="https://joe.bioscientifica.com/view/journals/joe/240/2/JOE-18-0532.xml" target="_blank" >https://joe.bioscientifica.com/view/journals/joe/240/2/JOE-18-0532.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1530/JOE-18-0532" target="_blank" >10.1530/JOE-18-0532</a>

Result language
angličtina
Original language name
The impact of anorexigenic peptides in experimental models of Alzheimer's disease pathology
Original language description
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the elderly population. Numerous epidemiological and experimental studies have demonstrated that patients who suffer from obesity or type 2 diabetes mellitu s have a higher risk of cognitive dysfunction and AD. Several recent studies demonstrat ed that food intakelowering (anorexigenic) peptides have the potential to improve metabolic disorders and that they may also potentially be useful in the treatment of neurodegenerative diseases. In this review, the neuroprotective effects of anorexigenic pept ides of both peripheral and central origins are discussed. Moreover, the role of leptin as a key modulator of energy homeostasis is discussed in relation to its interaction with anorexigenic peptides and their analogs in AD-like pathology. Although there is no pe rfect experimental model of human AD pathology, animal studies have already proven that anorexigenic peptides exhibit neuroprotective properties. This phenomenon is extremely important for the potential development of new drugs in view of the aging of the human population and of the significantly increasing incidence of AD.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30103 - Neurosciences (including psychophysiology)

Project
<a href="/en/project/GA16-00918S" target="_blank" >GA16-00918S: Neuroprotective effects of novel analogs of anorexigenic prolactin-releasing peptide (PrRP) in mouse models of neurodegeneration and obesity</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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