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No magnesium is needed for binding of the stimulator of interferon genes to cyclic dinucleotides

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00508878" target="_blank" >RIV/61388963:_____/19:00508878 - isvavai.cz</a>

  • Result on the web

    <a href="http://scripts.iucr.org/cgi-bin/paper?S2053230X19010999" target="_blank" >http://scripts.iucr.org/cgi-bin/paper?S2053230X19010999</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1107/S2053230X19010999" target="_blank" >10.1107/S2053230X19010999</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    No magnesium is needed for binding of the stimulator of interferon genes to cyclic dinucleotides

  • Original language description

    Stimulator of interferon genes (STING) binds cyclic dinucleotides (CDNs), which induce a large conformational change of the protein. The structural basis of activation of STING by CDNs is rather well understood. Unliganded STING forms an open dimer that undergoes a large conformational change (similar to 10 angstrom) to a closed conformation upon the binding of a CDN molecule. This event activates downstream effectors of STING and subsequently leads to activation of the type 1 interferon response. However, a previously solved structure of STING with 3',3'-c-di-GMP shows Mg atoms mediating the interaction of STING with this CDN. Here, it is shown that no Mg atoms are needed for this interaction, in fact, magnesium can in some cases obstruct the binding of a CDN to STING.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/EF16_019%2F0000729" target="_blank" >EF16_019/0000729: Chemical biology for drugging undruggable targets</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Acta Crystallographica Section F - Structural Biology Communications

  • ISSN

    2053-230X

  • e-ISSN

  • Volume of the periodical

    75

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    6

  • Pages from-to

    593-598

  • UT code for WoS article

    000484148400004

  • EID of the result in the Scopus database

    2-s2.0-85071736712