No magnesium is needed for binding of the stimulator of interferon genes to cyclic dinucleotides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00508878" target="_blank" >RIV/61388963:_____/19:00508878 - isvavai.cz</a>
Result on the web
<a href="http://scripts.iucr.org/cgi-bin/paper?S2053230X19010999" target="_blank" >http://scripts.iucr.org/cgi-bin/paper?S2053230X19010999</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1107/S2053230X19010999" target="_blank" >10.1107/S2053230X19010999</a>
Alternative languages
Result language
angličtina
Original language name
No magnesium is needed for binding of the stimulator of interferon genes to cyclic dinucleotides
Original language description
Stimulator of interferon genes (STING) binds cyclic dinucleotides (CDNs), which induce a large conformational change of the protein. The structural basis of activation of STING by CDNs is rather well understood. Unliganded STING forms an open dimer that undergoes a large conformational change (similar to 10 angstrom) to a closed conformation upon the binding of a CDN molecule. This event activates downstream effectors of STING and subsequently leads to activation of the type 1 interferon response. However, a previously solved structure of STING with 3',3'-c-di-GMP shows Mg atoms mediating the interaction of STING with this CDN. Here, it is shown that no Mg atoms are needed for this interaction, in fact, magnesium can in some cases obstruct the binding of a CDN to STING.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/EF16_019%2F0000729" target="_blank" >EF16_019/0000729: Chemical biology for drugging undruggable targets</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Crystallographica Section F - Structural Biology Communications
ISSN
2053-230X
e-ISSN
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Volume of the periodical
75
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
593-598
UT code for WoS article
000484148400004
EID of the result in the Scopus database
2-s2.0-85071736712