GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00510216" target="_blank" >RIV/61388963:_____/19:00510216 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10405475 RIV/00216208:11310/19:10405475
Result on the web
<a href="http://www.bioscience.org/2019/v24/af/4742/list.htm" target="_blank" >http://www.bioscience.org/2019/v24/af/4742/list.htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2741/4742" target="_blank" >10.2741/4742</a>
Alternative languages
Result language
angličtina
Original language name
GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond
Original language description
Glutamate carboxypeptidases II and III (GCPII and GCPIII) are highly homologous di-zinc metallopeptidases belonging to the M28 family. These enzymes are expressed in a variety of tissues, including the brain, prostate, kidney, testis and jejunum. GCPII has been recognized as a neuropeptidase in the central nervous system, as a folate hydrolase participating in absorption of folates in the jejunum and, most importantly, as a prostate-specific membrane antigen that is highly expressed in prostate adenocarcinoma. Furthermore, it has been identified in the neovasculature of most human solid tumors. In contrast, GCPIII has not been associated with any specific physiological function or pathology, and its expression, activity and inhibition have not been as well-studied. In this review, we provide an overview of the current understanding of the structure, enzymatic activity, substrate specificity, and tissue distribution of these two homologous enzymes. We discuss their potential physiological functions and describe the available animal models, including genetically modified mice. We also review the potential use of specific monoclonal antibodies and small-molecule inhibitors recognizing GCPII/III for diagnosis, imaging and experimental therapy of human cancers and other pathologies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/LO1302" target="_blank" >LO1302: InterBioMed</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Bioscience
ISSN
1093-9946
e-ISSN
—
Volume of the periodical
24
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
40
Pages from-to
648-687
UT code for WoS article
000488812800004
EID of the result in the Scopus database
2-s2.0-85062235620