Synthesis of water-soluble hypervalent iodine reagents for fluoroalkylation of biological thiols
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00518183" target="_blank" >RIV/61388963:_____/19:00518183 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2019/OB/C9OB02115A#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2019/OB/C9OB02115A#!divAbstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c9ob02115a" target="_blank" >10.1039/c9ob02115a</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis of water-soluble hypervalent iodine reagents for fluoroalkylation of biological thiols
Original language description
New open-chain and water-soluble hypervalent iodine reagents were synthesized and used for the transfer of fluoroalkyl groups to sulfur atoms of cysteine and cysteine-containing peptides under biocompatible conditions. Some of the reagents displayed excellent reactivity despite their limited stability in aqueous media. In reactions with a short cysteine-containing peptide, in addition to the expected S-fluoroalkylated product, a range of side-products were obtained. The amount of side-products depended on the conditions used (type of reagent, concentration, and pH). With highly activated hypervalent iodine reagents, a new reactive mode was observed reaction with disulfides to form fluoroalkyl thiols.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/GA17-00598S" target="_blank" >GA17-00598S: Development of fluoroalkylated hypervalent iodine reagents for thiol bioconjugations</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Organic & Biomolecular Chemistry
ISSN
1477-0520
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
47
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
10097-10102
UT code for WoS article
000501223800014
EID of the result in the Scopus database
2-s2.0-85076122984