A practical guide to biologically relevant molecular simulations with charge scaling for electronic polarization

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F20%3A00531628" target="_blank" >RIV/61388963:_____/20:00531628 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1063/5.0017775" target="_blank" >https://doi.org/10.1063/5.0017775</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1063/5.0017775" target="_blank" >10.1063/5.0017775</a>

Result language
angličtina
Original language name
A practical guide to biologically relevant molecular simulations with charge scaling for electronic polarization
Original language description
Molecular simulations can elucidate atomistic-level mechanisms of key biological processes, which are often hardly accessible to experiment. However, the results of the simulations can only be as trustworthy as the underlying simulation model. In many of these processes, interactions between charged moieties play a critical role. Current empirical force fields tend to overestimate such interactions, often in a dramatic way, when polyvalent ions are involved. The source of this shortcoming is the missing electronic polarization in these models. Given the importance of such biomolecular systems, there is great interest in fixing this deficiency in a computationally inexpensive way without employing explicitly polarizable force fields. Here, we review the electronic continuum correction approach, which accounts for electronic polarization in a mean-field way, focusing on its charge scaling variant. We show that by pragmatically scaling only the charged molecular groups, we qualitatively improve the charge–charge interactions without extra computational costs and benefit from decades of force field development on biomolecular force fields.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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