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Natural and magnetic circular dichroism spectra of nucleosides: effect of the dynamics and environment

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F21%3A00541262" target="_blank" >RIV/61388963:_____/21:00541262 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.1039/D1RA00076D" target="_blank" >https://doi.org/10.1039/D1RA00076D</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1039/d1ra00076d" target="_blank" >10.1039/d1ra00076d</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Natural and magnetic circular dichroism spectra of nucleosides: effect of the dynamics and environment

  • Original language description

    Chiroptical spectroscopic methods are excellent tools to study structure and interactions of biomolecules. However, their sensitivity to different structural aspects varies. To understand the dependence of absorption, electronic and magnetic circular dichroism (ECD, MCD) intensities on the structure, dynamics and environment, we measured and simulated spectra of nucleosides and other nucleic acid model components. The conformation space was explored by molecular dynamics (MD), the electronic spectra were generated using time dependent density functional theory (TDDFT). The sum over state (SOS) method was employed for MCD. The results show that accounting for the dynamics is crucial for reproduction of the experiment. While unpolarized absorption spectroscopy is relatively indifferent, ECD reflects the conformation and geometry dispersion more. MCD spectra provide variable response dependent on the wavelength and structural change. In general, MCD samples the structure more locally than ECD. Simple computational tests suggest that the optical spectroscopies coupled with the computational tools provide useful information about nucleic acid components, including base pairing and stacking.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10403 - Physical chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    RSC Advances

  • ISSN

    2046-2069

  • e-ISSN

    2046-2069

  • Volume of the periodical

    11

  • Issue of the periodical within the volume

    14

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

    8411-8419

  • UT code for WoS article

    000622073000065

  • EID of the result in the Scopus database

    2-s2.0-85101635046