A new method for double bond characterization in lipids by ultraviolet photodissociation mass spectrometry

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F21%3A00551883" target="_blank" >RIV/61388963:_____/21:00551883 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/21:10442139
Result on the web
<a href="http://web.natur.cuni.cz/analchem/isc/isc17.pdf" target="_blank" >http://web.natur.cuni.cz/analchem/isc/isc17.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
A new method for double bond characterization in lipids by ultraviolet photodissociation mass spectrometry
Original language description
Lipids are structurally diverse biomolecules with vital functions in biological systems. Some of these functions are closely associated with the specific location of the carbon-carbon double bond in the lipid acyl chains. The chain length and the number of unsaturated carbon-carbon bonds can be determined using conventional MS/MS-based structural elucidation methods employing low or higher energy collision-induced dissociation. However, these dissociation techniques do not provide more subtle structural details, for example, the position of unsaturated bonds. Another type of activation method – ultraviolet photodissociation can be used for this purpose. In this study, a new method for characterization of double bond location in lipids acyl chain was developed using 193 nm ultraviolet photodissociation implemented on Orbitrap Fusion Lumos mass spectrometer. This approach is based on the derivatization of the double bond with bis-(5-iodo-[2]pyridyl)-disulfide, subsequent specific cleavages provide a unique diagnostic pair bearing information about the double bond position.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the 17th international students conference 'Modern Analytical Chemistry'
ISBN
978-80-7444-089-2
ISSN
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e-ISSN
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Number of pages
7
Pages from-to
193-199
Publisher name
Univerzita Karlova, Přírodovědecká fakulta
Place of publication
Praha
Event location
Praha
Event date
Sep 16, 2021
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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