5′-Phosphonate modified oligoadenylates as potent activators of human RNase L

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00552686" target="_blank" >RIV/61388963:_____/22:00552686 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/22:10441482

Result on the web

<a href="https://doi.org/10.1016/j.bmc.2022.116632" target="_blank" >https://doi.org/10.1016/j.bmc.2022.116632</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bmc.2022.116632" target="_blank" >10.1016/j.bmc.2022.116632</a>

Result language

angličtina

Original language name

5′-Phosphonate modified oligoadenylates as potent activators of human RNase L

Original language description

The oligoadenylate synthetase-ribonuclease L pathway is a major player in the interferon-induced antiviral defense mechanism of cells. Upon sensing viral dsRNA, 5'-phosphorylated 2',5'-oligoadenylates are synthesized, and subsequently activate latent RNase L. To determine the influence of 5'-phosphate end on the activation of human RNase L, four sets of 5'-phosphonate modified oligoadenylates were prepared on solid-phase. The ability of these 5'-modified oligoadenylates bearing shortened, isosteric and prolonged phosphonate linkages to activate RNase L was explored. We found that isosteric linkages and linkages prolonged by one atom were in general well tolerated by the enzyme with the EC50 values comparable to that of the natural activator. In contrast, linkages shortened by one atom or prolonged by two atoms exhibited decrease in the activity.

Czech name

—

Czech description

—

Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/EF16_019%2F0000729" target="_blank" >EF16_019/0000729: Chemical biology for drugging undruggable targets</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioorganic & Medicinal Chemistry

ISSN

0968-0896

e-ISSN

1464-3391

Volume of the periodical

56

Issue of the periodical within the volume

Feb 15

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

116632

UT code for WoS article

000968229100006

EID of the result in the Scopus database

2-s2.0-85123194690